Why is personalized treatment different?

For decades, neuropathy treatment followed generic protocols: painkillers, antidepressants, anticonvulsants, and physical therapy.

While these options help, they don't always address the underlying cause of each person's pain.

Personalized treatment goes further: it seeks to understand the biological, genetic and clinical profile of each patient before defining the best approach.

Among the factors evaluated are:

• Type of neuropathy (diabetic, idiopathic, inflammatory, etc.) ;

• Level of nerve involvement (sensory, motor or mixed);

• Comorbidities (such as hypertension, depression, obesity or anxiety);

• Individual response to medications ;

• Lifestyle and daily habits .

• From there, the doctor creates a tailored plan, which may combine pharmacological, physical and complementary therapies.

Modern treatments used in a personalized approach

Advances in science in recent years have brought new therapeutic options that allow treatment to be tailored to each patient's needs.

The main options include:

• Regenerative therapies

• Treatments like VM202 (Engensis) , currently being studied in the United States, use gene therapy to stimulate the growth of new blood vessels and nerve fibers.

• This approach has shown promising results in cases of painful diabetic neuropathy.

Neuromodulation

• Through electrical or magnetic stimuli, techniques such as transcranial stimulation or peripheral neurostimulation help to “reprogram” the nervous system, reducing sensitivity to pain.

• These therapies are indicated for patients who do not respond well to conventional medications.

• Physiotherapy and personalized exercises

• Physical rehabilitation is a fundamental part of treatment.

• Specific exercises help:

• Improve balance and muscle strength;

• Stimulate nerve regeneration;

• Reduce pain and tingling.

• Personalized programs consider each patient's level of limitation and pain tolerance.

Nutrition and supplementation

• Nutritional deficiencies, especially of vitamin B12, alpha-lipoic acid, and omega-3s , can worsen neuropathy.

• Nutritional monitoring is essential to balance metabolism and support nerve regeneration.

Mental health and chronic pain

• Neuropathic pain is also an emotional experience.

• Personalized programs include cognitive therapies and mindfulness practices , which help the brain modulate pain perception and improve quality of life.

Precision Medicine: The Future Has Already Begun

With advances in genetic testing and artificial intelligence, personalized medicine is becoming increasingly accessible.

Some research centers in the United States are already using algorithms that analyze DNA and clinical history to predict which treatments will be most effective and have the lowest risk of adverse effects .

This is the basis of so-called “precision medicine” — a model of care that considers the patient as a whole individual , not just a diagnosis.

Conclusion: treat neuropathy in a unique way, like each patient

Personalized treatment represents a profound shift in the way neuropathy is treated.

It combines technology, science, and human sensitivity to understand each person's pain in its entirety .

Instead of adapting the patient to the treatment, now the treatment adapts to the patient.

The future of neurology and pain lies in personalization—and with it comes new hope for those who live daily with the challenges of neuropathy.